A study found that prostate cancer-suppressing drugs may increase the risk of heart attack. This surprising discovery, reduced enthusiasm for use of the drug.
Previously, GlacoSmithKline PLC asking FDA (Food and Drug Inspection Institute for the U.S.) to approve the drug Avodart for cancer prevention for men with risk above the average for this disease. This medicine has been used for a problem urinating and no cardiac risk of such use, said the doctor.
“The conclusion from this study as an antidote to cancer is mentioned at medical conferences years ago, but no known cardiac risk information at the time,” said Glaxo spokeswoman.
Overall results of this study can be viewed at the New England Journal Of Medicine edition this Thursday.
This study followed 6700 men with a high value of the blood test PSA, but no sign of cancer on biopsy. They were then given a fake pill Avodart and as well as a new biopsy for four years. Prostate cancer was found in 25% of those using fake pills and 20% users Avodart.
This is the same risk reduction with another study which found him in the same drug, Finasteride, which is sold in generic form as Proscar, manufactured by Merck & Co.. Inc. This research found no higher risk of heart attack on Proscar. In the study, Avodart, heart failure developed in 30 men compared to 16 drug users from fake pills.
“Further analysis suggested for men at risk of heart failure during the use of Avodart was also inclined to use an additional drug,” said a spokesman for Glaxo, Sarah Alspach. He added that the high risk of heart failure was considered not described and not consistent with previous research.
Last year, a discussion panel of cardiologists to recommend men choose Proscar or Avodart if they regularly tend to prostate cancer. However, Avodart study is not compatible with previous suggestions.
“Two of these drugs work with the different ways and may not have the same safety profile,” said Dr. Barnett Krammer, scientists from the National Institutes of Health who led the panel and no relation with the research.
Avodart In overall conclusion, according to Kramer’s most important is the possibility of heart attacks that have not been anticipated.
Dr. Otis Brawley, who helped research this before becoming the head of the American Cancer Medical Society in 2007, said that heart attack risk may be a coincidence. However, men may need to pay attention to this risk. “This is probably a good reason to stop the consumption of the drug,” said Brawley.
The number of people who choose to use these drugs for cancer prevention has not been clear until now. On the other hand, the cost is about U.S. $ 3 per pill. ‘To prevent additional cases of cancer, men should consume 71 Proscar for the past seven years, “says doctor
Nonskin cancer, prostate cancer is most common in American men. Approximately 192 000 new cases and 27 000 deaths from cancer occurred last year.
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