Now the Adam can prepare yourself if one day he would be attacked by prostate cancer. A study found the gene that triggers cancer into a nightmare of him.
For the Eve, a cancer that could have become a nightmare of breast cancer or cervical cancer. For those of Adam, the nightmare is prostate cancer. Later, a disease caused by malignant cells in the prostate gland is increasingly widespread. While in Asia are still relatively few sufferers, the data from 13 countries in Indonesia Faculty of Medicine indicates prostate cancer included in the 10 most common malignant disease in men. On the Subdivision of Urology, Faculty of Medicine of surgery, University of Indonesia (Faculty of medicine), during the period 1995 to 1998 found an average 17 cases per year and ranked second after jar of cancer (bladder). This figure can not be ignored because the disease kills about 10,000 men each case.
E2F3 gene
Now, thanks to the results of a study conducted by researchers from Institute of Cancer Research Everyman Center, men can breathe a little sigh of relief. They have discovered a gene called E2F3, genes that are considered as triggers prostate cancer, such as quoted by BBC News Online recently. Previous E2F3 gene is also detected as the cause of bladder cancer. These genes actually have an important role as controller cell division in the body of living creatures
In the case of prostate cancer cells, this applies overactive E2F3 gene, which produces too much protein. The result is excessive cell proliferation and tumor development. The team of scientists have measured the E2F3 protein in the prostate sample 147 men and see how many levels of E2F3 in each cell. Found none of healthy prostate cells. E2F3 gene precisely and absent by 67 percent of prostate cancer cells. The higher the amount of protein is, the more aggressive cancers also suffered.
"This finding is quite encouraging, because the cause is unknown. From here it could be a marker gene in prostate cancer diagnosis, "said Professor Colin Cooper, head of the study told BBC News Online. "The test to distinguish aggressive tumors, causes, and where the tumor is of minor importance in prostate cancer research."
Often the case of a patient undergoing medical procedures that are not really necessary. But because it's not a diagnosis of prostate cancer can be so accurate so each patient would not want to live it. Now known already that the E2F3 gene plays an active role in prostate cancer as a key identifier how aggressive the cancer grows.
PSA test
Until recently, the majority of medical experts around the world using Prostate Specific Antigen test (PSA) to assess the presence of prostate cancer. This test is less accurate to happen took serious action for the cancer that was mild. This test is also unable to know whether the cancer grow faster or slower.
PSA is a single chain glycoprotein consisting of 237 amino acids and four carbohydrate side chains. PSA found on cells from asini sekretik so that PSA is prostate-specific substances prostate organ, and therefore can be found in normal prostate, prostatic hyperplasia and prostate cancer. PSA levels in serum depending on the size of the prostate. In benign prostate enlargement, the PSA derived from the transitional zone, but in prostate cancer is much higher.
In serum PSA levels usually measured by Radio Immuno Assay (RIA). PSA in serum can also be raised in circumstances such as inflammatory (prostatitis), action catheterization, digital rectal examination or a cystoscopy and TURP (Trans urethra resection of the Prostate).
Whereas in the prostate tissue, PSA can be identified with immuno peroxidase staining on preparations pathology. PSA levels are useful to follow the course of the disease on the response of prostate cancer treatment or surgery that has been done.
In addition to recognition as a trigger for prostate cancer, E2F3 gene is also considered as a cause of bladder cancer. Cancer is no less ferocious than prostate cancer. In Indonesia, based on the data collection network assessment conducted during 1988-1990, it is known that bladder cancer ranks tenth of primary malignant tumors in men. Actually this disease is not the Adam's illness, but also the Eve. But records show the man three times greater risk of cancer of the bladder.
Cooper and his research team discovered that there was a lot of double the amount of E2F3 gene in some patients with bladder cancer. Also evident from the analysis of a direct link between the amount of E2F3 and stage of cancer. The findings are expected later could be a reference in the treatment of bladder cancer in the future. In addition to blocking the gene in a patient, is also expected later created a boutique-style treatment where medical procedures are performed on each patient are different from each other, determined by the level of its genes.
"This treatment is far more effective because each patient can be immediately known genetic condition, whether it pertained great potential cancer or not," explained Cooper. The finding was welcomed by cancer experts throughout the world. Professor Peter Rigby, chairman of the Institute of Cancer Research commented, "We await other findings from this study and can anticipate the development of prostate and bladder cancer early."
Prostate cancer is a malignant cancer affecting men over the age of 50 years old. Usually if there are family members of prostate cancer, the other high-risk family members also have it later. Strangely the disease is fairly rare attacking Asian people. More of the white race or black suffering.
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