Now the Adam can prepare yourself if one day he would be attacked by prostate cancer. A study found the gene that triggers cancer into a nightmare of him.
For the Eve, a cancer that could have become a nightmare of breast cancer or cervical cancer. For those of Adam, the nightmare is prostate cancer. Later, a disease caused by malignant cells in the prostate gland is increasingly widespread. While in Asia are still relatively few sufferers, the data from 13 countries in Indonesia Faculty of Medicine indicates prostate cancer included in the 10 most common malignant disease in men. On the Subdivision of Urology, Faculty of Medicine of surgery, University of Indonesia (Faculty of medicine), during the period 1995 to 1998 found an average 17 cases per year and ranked second after jar of cancer (bladder). This figure can not be ignored because the disease kills about 10,000 men each case.
E2F3 gene
Now, thanks to the results of a study conducted by scientists from the Institute of Cancer Research Everyman Centre, men can breathe a little sigh of relief. They have discovered a gene called E2F3, genes that are considered as triggers prostate cancer, such as quoted by BBC News Online recently. Previous E2F3 gene is also detected as the cause of bladder cancer. These genes actually have an important role as controller cell division in the body of living creatures.
In the case of prostate cancer cells, this applies overactive E2F3 gene, which produces too much protein. The result is excessive cell proliferation and tumor development. The team of scientists have measured the E2F3 protein in the prostate sample 147 men and see how many levels of E2F3 in each cell. Found none of the healthy prostate cells. E2F3 gene precisely and absent by 67 percent of prostate cancer cells. The higher the amount of protein is, the more aggressive cancers also suffered.
"This finding is quite encouraging, because the cause is unknown. From here it could be a marker gene in prostate cancer diagnosis, "said Professor Colin Cooper, head of the study told BBC News Online. "The test to distinguish aggressive tumors, causes, and where the tumor is of minor importance in prostate cancer research."
Often the case of a patient undergoing medical procedures that are not really necessary. However, because prostate cancer diagnosis has not been able to so accurately so each patient would not want to live it. Now known already that the E2F3 gene plays an active role in prostate cancer as a key identifier how aggressive the cancer grows.
PSA test
Until recently, the majority of medical experts around the world using Prostate Specific Antigen test (PSA) to determine the presence of prostate cancer. This test is less accurate to happen took serious action for the cancer that was mild. This test is also unable to know whether the cancer grows rapidly or slowly.
PSA is a single chain glycoprotein consisting of 237 amino acids and four carbohydrate side chains. PSA found on cells from asini sekretik so that PSA is prostate-specific substances prostate organ, and therefore can be found in normal prostate, prostatic hyperplasia and prostate cancer. PSA levels in serum depending on the size of the prostate. In benign prostate enlargement, the PSA derived from the transitional zone, but in prostate cancer is much higher.
In serum PSA levels usually measured by Radio Immuno Assay (RIA). PSA in serum can also be raised in circumstances such as inflammation (prostatitis), action catheterization, digital rectal examination or a cystoscopy and TURP (Trans urethra resection of the Prostate).
Whereas in the prostate tissue, PSA can be identified by immuno peroxidase staining on preparations pathology. PSA levels are useful to follow the course of the disease on the response of prostate cancer treatment or surgery that has been done.
In addition to recognition as a trigger for prostate cancer, E2F3 gene is also considered as a cause of bladder cancer. Cancer is no less ferocious than prostate cancer. In Indonesia, based on the data collection network assessment conducted during 1988-1990, it is known that bladder cancer ranks tenth of primary malignant tumors in men. Actually this disease is not the Adam's illness, but also the Eve. But records show the man three times greater risk of cancer of the bladder.
Cooper and his research team discovered that there was a lot of double the amount of E2F3 gene in some patients with bladder cancer. From the analysis also proved the existence of a direct link between the amount of E2F3 and stage of cancer. The findings are expected later could be a reference in the treatment of bladder cancer in the future. In addition to blocking the gene in a patient, is also expected later created a boutique-style treatment where medical procedures are performed on each patient are different from each other, determined by the level of its genes.
"This treatment is far more effective because each patient can be immediately known genetic condition, whether it pertained great potential cancer or not," explained Cooper. The finding was welcomed by cancer experts throughout the world. Professor Peter Rigby, chairman of the Institute of CancerResearch commented, "We await other findings from this study and can anticipate the development of prostate and bladder cancer early."
Prostate cancer is a malignant cancer that attacks man over the age of 50 years. Usually if there are family members of prostate cancer, the other high-risk family members also have it later. Strangely this disease quite rare attack Asians.
Benign Prostate Enlargement
Health Disorders in Men Aged 50 and Over
Jakarta, Sinar Harapan
Health problems in old age is not only dominated womanhood, but also of Adam. If women had clinical problems related to the women, even so with man. At the age of 50 years, men often experience what is called benign prostate enlargement.
Benign prostate enlargement symptoms when you first start clogging prostate enlargement urinary flow
"Usually this disease has symptoms of a weak urine stream, urinating disconnected and dissatisfied urinate because urine is left feeling," explained Dr. Iwan Asmara, Spb, urology staff at the Faculty of Medicine, University of Indonesia (Faculty of medicine) in a seminar themed "Benign Prostate Enlargement, Early Detection and Handling" held Husada Hospital in Jakarta. Additionally, followed by wetting or uncontrolled urination, and increased frequency on the day or night.
Briefly, the disease seemed mild and not dangerous, but enough to disrupt daily activities and of course the person becomes uncomfortable.
And if allowed to drag on then it could be fatal. Small veins of the urethra and bladder can rupture when the patient straining while urinating, which causes blood in the urine. Total blockage can make the patient could not urinate, which eventually led to full and then feeling pain in his lower abdomen
In epidemiology, said 50 percent of men will experience this benign prostate enlargement. And the majority of its handling is by surgery. Thanks to the progress of science, surgical procedures can be suppressed. Last known that 60 percent of cases of benign prostate enlargement can be overcome with medical treatment and only 15 percent ended with surgery alone.
Treatment
Before determining the actions taken, the patient must first undergo initial examination. Here will be monitored medical history, measurement of quality of symptoms, physical examination, blood check, and check your urine. According to Jasmine, urine examination was done by measuring residual urine, urine flow pressure with Urodynamics, prostate imaging with ultra sonografik (USG) or transabdominal ultrasound (TAUS) and transectal ultrasound (then), as well as imaging of other organs such as kidney and the ureter associated with ultrasound and x-rays. Followed by lower urinary tract binoculars with endoscopic techniques.
"Initial Inspection can be chosen among others by using TAUS procedures, namely measuring the residual urine, prostate shape, size and volume of the prostate to the configuration and the protrusion of the prostate," said Iwan. Another type of inspection is then performed detection where suspicion of malignancy that can be known through ultrasound and prostate biopsy with a needle. While the upper urinary tract imaging with ultrasound and x-ray series performed on patients who have a history or upper urinary tract infections.
This procedure applies to patients experiencing urinating blood, and renal failure. While binoculars endoscopy applied to patients who want to do alternative therapies and surgical interventions before treatment. But it is not recommended for cases of other benign prostate enlargement.
Iwan elicit, in addition to surgical procedures can be prevented by drug administration. Type of medicine here is the standard choice for a special urinary disorders caused by benign prostate enlargement, but not others. Usually given medication type Alpha-1 adrenergic blockers, namely the first-line drugs recommended by the World Health Organization (WHO).
For the Eve, a cancer that could have become a nightmare of breast cancer or cervical cancer. For those of Adam, the nightmare is prostate cancer. Later, a disease caused by malignant cells in the prostate gland is increasingly widespread. While in Asia are still relatively few sufferers, the data from 13 countries in Indonesia Faculty of Medicine indicates prostate cancer included in the 10 most common malignant disease in men. On the Subdivision of Urology, Faculty of Medicine of surgery, University of Indonesia (Faculty of medicine), during the period 1995 to 1998 found an average 17 cases per year and ranked second after jar of cancer (bladder). This figure can not be ignored because the disease kills about 10,000 men each case.
E2F3 gene
Now, thanks to the results of a study conducted by scientists from the Institute of Cancer Research Everyman Centre, men can breathe a little sigh of relief. They have discovered a gene called E2F3, genes that are considered as triggers prostate cancer, such as quoted by BBC News Online recently. Previous E2F3 gene is also detected as the cause of bladder cancer. These genes actually have an important role as controller cell division in the body of living creatures.
In the case of prostate cancer cells, this applies overactive E2F3 gene, which produces too much protein. The result is excessive cell proliferation and tumor development. The team of scientists have measured the E2F3 protein in the prostate sample 147 men and see how many levels of E2F3 in each cell. Found none of the healthy prostate cells. E2F3 gene precisely and absent by 67 percent of prostate cancer cells. The higher the amount of protein is, the more aggressive cancers also suffered.
"This finding is quite encouraging, because the cause is unknown. From here it could be a marker gene in prostate cancer diagnosis, "said Professor Colin Cooper, head of the study told BBC News Online. "The test to distinguish aggressive tumors, causes, and where the tumor is of minor importance in prostate cancer research."
Often the case of a patient undergoing medical procedures that are not really necessary. However, because prostate cancer diagnosis has not been able to so accurately so each patient would not want to live it. Now known already that the E2F3 gene plays an active role in prostate cancer as a key identifier how aggressive the cancer grows.
PSA test
Until recently, the majority of medical experts around the world using Prostate Specific Antigen test (PSA) to determine the presence of prostate cancer. This test is less accurate to happen took serious action for the cancer that was mild. This test is also unable to know whether the cancer grows rapidly or slowly.
PSA is a single chain glycoprotein consisting of 237 amino acids and four carbohydrate side chains. PSA found on cells from asini sekretik so that PSA is prostate-specific substances prostate organ, and therefore can be found in normal prostate, prostatic hyperplasia and prostate cancer. PSA levels in serum depending on the size of the prostate. In benign prostate enlargement, the PSA derived from the transitional zone, but in prostate cancer is much higher.
In serum PSA levels usually measured by Radio Immuno Assay (RIA). PSA in serum can also be raised in circumstances such as inflammation (prostatitis), action catheterization, digital rectal examination or a cystoscopy and TURP (Trans urethra resection of the Prostate).
Whereas in the prostate tissue, PSA can be identified by immuno peroxidase staining on preparations pathology. PSA levels are useful to follow the course of the disease on the response of prostate cancer treatment or surgery that has been done.
In addition to recognition as a trigger for prostate cancer, E2F3 gene is also considered as a cause of bladder cancer. Cancer is no less ferocious than prostate cancer. In Indonesia, based on the data collection network assessment conducted during 1988-1990, it is known that bladder cancer ranks tenth of primary malignant tumors in men. Actually this disease is not the Adam's illness, but also the Eve. But records show the man three times greater risk of cancer of the bladder.
Cooper and his research team discovered that there was a lot of double the amount of E2F3 gene in some patients with bladder cancer. From the analysis also proved the existence of a direct link between the amount of E2F3 and stage of cancer. The findings are expected later could be a reference in the treatment of bladder cancer in the future. In addition to blocking the gene in a patient, is also expected later created a boutique-style treatment where medical procedures are performed on each patient are different from each other, determined by the level of its genes.
"This treatment is far more effective because each patient can be immediately known genetic condition, whether it pertained great potential cancer or not," explained Cooper. The finding was welcomed by cancer experts throughout the world. Professor Peter Rigby, chairman of the Institute of CancerResearch commented, "We await other findings from this study and can anticipate the development of prostate and bladder cancer early."
Prostate cancer is a malignant cancer that attacks man over the age of 50 years. Usually if there are family members of prostate cancer, the other high-risk family members also have it later. Strangely this disease quite rare attack Asians.
Benign Prostate Enlargement
Health Disorders in Men Aged 50 and Over
Jakarta, Sinar Harapan
Health problems in old age is not only dominated womanhood, but also of Adam. If women had clinical problems related to the women, even so with man. At the age of 50 years, men often experience what is called benign prostate enlargement.
Benign prostate enlargement symptoms when you first start clogging prostate enlargement urinary flow
"Usually this disease has symptoms of a weak urine stream, urinating disconnected and dissatisfied urinate because urine is left feeling," explained Dr. Iwan Asmara, Spb, urology staff at the Faculty of Medicine, University of Indonesia (Faculty of medicine) in a seminar themed "Benign Prostate Enlargement, Early Detection and Handling" held Husada Hospital in Jakarta. Additionally, followed by wetting or uncontrolled urination, and increased frequency on the day or night.
Briefly, the disease seemed mild and not dangerous, but enough to disrupt daily activities and of course the person becomes uncomfortable.
And if allowed to drag on then it could be fatal. Small veins of the urethra and bladder can rupture when the patient straining while urinating, which causes blood in the urine. Total blockage can make the patient could not urinate, which eventually led to full and then feeling pain in his lower abdomen
In epidemiology, said 50 percent of men will experience this benign prostate enlargement. And the majority of its handling is by surgery. Thanks to the progress of science, surgical procedures can be suppressed. Last known that 60 percent of cases of benign prostate enlargement can be overcome with medical treatment and only 15 percent ended with surgery alone.
Treatment
Before determining the actions taken, the patient must first undergo initial examination. Here will be monitored medical history, measurement of quality of symptoms, physical examination, blood check, and check your urine. According to Jasmine, urine examination was done by measuring residual urine, urine flow pressure with Urodynamics, prostate imaging with ultra sonografik (USG) or transabdominal ultrasound (TAUS) and transectal ultrasound (then), as well as imaging of other organs such as kidney and the ureter associated with ultrasound and x-rays. Followed by lower urinary tract binoculars with endoscopic techniques.
"Initial Inspection can be chosen among others by using TAUS procedures, namely measuring the residual urine, prostate shape, size and volume of the prostate to the configuration and the protrusion of the prostate," said Iwan. Another type of inspection is then performed detection where suspicion of malignancy that can be known through ultrasound and prostate biopsy with a needle. While the upper urinary tract imaging with ultrasound and x-ray series performed on patients who have a history or upper urinary tract infections.
This procedure applies to patients experiencing urinating blood, and renal failure. While binoculars endoscopy applied to patients who want to do alternative therapies and surgical interventions before treatment. But it is not recommended for cases of other benign prostate enlargement.
Iwan elicit, in addition to surgical procedures can be prevented by drug administration. Type of medicine here is the standard choice for a special urinary disorders caused by benign prostate enlargement, but not others. Usually given medication type Alpha-1 adrenergic blockers, namely the first-line drugs recommended by the World Health Organization (WHO).
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